Anti-HIV-1 and anti-HIV-1-protease substances from Ganoderma lucidum.

el-Mekkawy S, Meselhy MR, Nakamura N, Tezuka Y, Hattori M, Kakiuchi N, Shimotohno K, Kawahata T, Otake T.

Research Institute for Traditional Sino-Japanese Medicines, Toyama Medical and Pharmaceutical University, Japan.

A new highly oxygenated triterpene named ganoderic acid alpha has been isolated from a methanol extract of the fruiting bodies of Ganoderma lucidum together with twelve known compounds. The structures of the isolated compounds were determined by spectroscopic means including 2D-NMR. Ganoderiol F and ganodermanontriol were found to be active as anti-HIV-1 agents with an inhibitory concentration of 7.8 micrograms ml-1 for both, and ganoderic acid B, ganoderiol B, ganoderic acid C1, 3 beta-5 alpha-dihydroxy-6 beta-methoxyergosta-7,22-diene, ganoderic acid alpha, ganoderic acid H and ganoderiol A were moderately active inhibitors against HIV-1 PR with a 50% inhibitory concentration of 0.17-0.23 mM.

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Some outstanding results obtained recently are simply analyzed below, in order to evaluate the efficacy of Ganoderma

1. Headache and shoulder pain caused by hypertension and arteriosclerosis are completely cured, and blood pressure also improved.
Reported by mr. Isao Tani of the Medical Research Institute of Kinki University.

The experimental subjects were predominantly hypertension patients. Blood pressure showed significant improvement. One patient with reading of 180/96, had a reading of 126/94 after three months. Such remarkable improvement is rarely seen without using antihypersentive medicine.

Some female arteriosclerosis patients' blood pressure dropped to 128/67 from 158/77, within three months. Their cholesterol level also improved from 269 to 242.

Some patients have hypertension with headache and shoulder pain. Their blood pressure dropped form 151/78 to 118/72 in one month, and headaches were eliminated.

Of a number of patients who had blood pressure and pain problems, both conditions improved.

Based on the above results, we may see that Ganoderma is useful to hypertension patients. using anti-hypertensive to lower blood pressure can lower the systolic pressure, but not the diastolic pressure. Ganoderma can lower both. This is its outstanding quality.

2. Why is it effective for both systolic and diastolic pressure?
Dr. Shigere Yuji of Kinki University give six explanations why Ganoderma is effective for cardio-vascular diseases.

a. Treats hypertension.
b. Elevates blood pressure of hypotensive patients.
c. Prevents arteriosclerosis and lowers cholesterol level.
d. Prevents thrombogenesis and dissolves thrombi.
e. Reduces the side effects of antihypertensive.
f. used together with hypertnesive, causes a hypotensive effect.

3. It is also effective in treating cerebral vascular obstruction, cardiac infraction and cerebral apoplexy and angina pectoris.
Reported by Mr. Uebara Kioshi of Kinki University

Taking Ganoderma can reduce the serious symptoms of the above diseases, without traditional treatment. Among these cases, was a patient with a right cerebral arterial obstruction which occured twice. He received the best result after taking Ganoderma and Urokinase, together. Complete mobility finally returned.

A patient suffering from cerebral vascular obstruction, who was partially paralayzed, could move freely after taking Ganoderma. His free fat and B-lipo protein value returned to normal.

Taking Ganoderma together improve the condition of cardiac patients. This proves that taking Ganoderma together with other drugs, may result in better result. By the way, since the above diseases are difficult to cure, it is better to take Ganoderma regularly to prevent their occuring in the first place.

4.It is effective in the treatment of acute or chronic hepatitis, or liver dysfunction.
Reported by Dr. Mitsui Hashimoto of Hashimoto Hospital

At the present time, hepatitis is still a disease, which can not be treated with any specific method. If Ganoderma is effective, it would be a meaningful medicine for its treatment.

Six capsules per day were prescribed to some patients with hepatitis. Three months later, all patients were recoverin, their GOT and GPT values decreased from 200-300 to 100.

In addition, one patient who used Ganoderma together with some Chinese herbal medicines resulted in a decreased GOT and GPT. There was one case of hepatitis combined with hypertension. After taking Ganoderma, satisfactory results were obtained.

The above conditions can not be conclusive, but positive results of taking Ganoderma on hepatitis can be expected.

When liver function is declining, the patient may get tired. Taking Ganoderma can help ease fatigue.

5. The believe that 'Liver disease is incurable' should be abandoned.
The liver is the most important organ for health. Liver function is quite complicated. Therefore, liver diseases are considered difficult to treat, and dietetic treatment is the only method adopted by Westerns physicians.

However, Ganoderma is able to make the complicated organ function and bring it back to normal. Based on our practical investigation. Ganoderma can contribute a very positive effect. Dr. Shigeru Yuji reported that 10% of liver disorders could be cured after taking for two months. 40% of the patients were relieved of their symptoms, and their liver size was reduced. 50% of the patients felt their symptoms diminished.


DISCLAIMER

Despite all the possible health benefits that can be obtained from Ganoderma Lucidum, it is not intended to replace the recommendations of a medical doctor. This product is not sold as a drug but a "Food Supplement". Patients with specific problem should always consult their physician. All health benefit claims are based on reports of researches made by scientists in Japan.

The Japanese medical field has confirmed that Ganoderma has positive efficacy.

Physicians all over the world are concerned about high quality medicines. A new medical term "Adaptogen" has been coined to indicate the specific effects of Ganoderma.

After long term research and experiments done by large Japanese hospitals and research institutues. Ganoderma's positive effects have been confirmed in every respect, especially its hemocatharsis effect, e.e., improves a weak constitution, and enhances the immune system. It has an evident efficacy in treating diseases caused by poor circulation. It is helpful in maintaining healthy and healthy appearance. The Japanese medical field is surprised and has acknowledged its positive effects on the following diseases:

1. hypertension and hypotension
2. cardiac disease originating from hypertension and hematoma
3. cerebral apoplexy, high blood sugar, blood vessel obstruction
4. menopause disturbances, gynecological diseases
5. constipation. hemorrhoids
6. chronic hepatitis
7. urination difficulties, frequent urination
8. gastric diseases, duodenal ulcers
9. hypersensitivity, including nasal sensitivity and chronic catarrh
10. chronic bronchitis, asthma
11. arthritis, lumbago, rheumatism (after middle age)
12. insomnia, lethargy, neurasthenia
13. skin rashes due to hypersensitivity, athlete's foot, and ringworm due to hematoma

It may sound strange that Ganoderma has an inverse effect, i.e., it can both raise and lower blood pressure. Actually, because Ganoderma can harmonize body functions, increasing the natural healing ability of the body, it can strengthen the immune system, especially for the middle aged.

With Ganoderma, some people may experience reactions after beginning treatment. Some may have dizziness, weakness, or itching, or repeated defecation and urination. These are normal phenomena which indicate that the positive effects are beginning, by dissolving the stored toxicants and discharging them. Patients with diabetes may lose a large amount of sugar, patients with rheumatism may have temporary intense pain. These phenomena are purely the normal, functional, adjustments, within the body. It is nothing but the performance of its efficacy. According to one's personal constitution, the reactions will disappear in a few days.

Since Ganoderma is a natural medicine, it can be used with other Western drugs. Not only are there no adverse, it can also reduce the side effects of Western drugs.